The observation that a subset of cancer patients show evidence for spontaneous CD8+ T
cell priming against tumor-associated antigens has generated renewed interest in the innate …

The discovery of cancer immune surveillance and immunotherapy has opened up a new era
of cancer treatment. Immunotherapies modulate a patient's immune system to specifically …

Despite lack of tumor control in many models, spontaneous T cell priming occurs frequently
in response to a growing tumor. However, the innate immune mechanisms that promote …

A characteristic feature of tumors is high production of lactic acid due to enhanced
glycolysis. Here, we show a positive correlation between lactate serum levels and tumor …

Unexpectedly, many cancers appear to induce a spontaneous adaptive T cell response. The
presence of a T cell infiltrate has been linked to favorable clinical outcome in multiple cancer …

Epithelial-to-mesenchymal transition (EMT) mediates cancer cell invasion, metastasis, and
drug resistance, but its impact on immune surveillance has not been explored. In this study …

The concept of therapeutic cancer vaccines is based on the activation of the immune system
against tumor cells after the presentation of tumor antigens. Nanoparticles (NPs) have …

The priming of an appropriate anti‐tumor T cell response rarely results in the rejection of
established tumors. The characteristics of tumors that allow them to evade a T cell‐mediated …

Although tumor-specific CD8 T-cell responses often develop in cancer patients, they rarely
result in tumor eradication. We aimed at studying directly the functional efficacy of tumor …

Many human tumor-associated antigens (TAAs) have recently been identified and
molecularly characterized. When bound to major histocompatibility complex molecules, TAA …