Caspase-3 is a widely expressed member of a conserved family of proteins, generally
recognized for their activated proteolytic roles in the execution of apoptosis in cells …

Reactive oxygen and nitrogen species (RONS) are generated through various endogenous
and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic …

Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations
exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How …

The MTT assay for cellular metabolic activity is almost ubiquitous to studies of cell toxicity;
however, it is commonly applied and interpreted erroneously. We investigated the …

Over the last few decades, various forms of regulated cell death (RCD) have been
discovered and were found to improve cancer treatment. Although there are several reviews …

This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …

The NLRP3 inflammasome is a cytosolic multiprotein complex composed of the innate
immune receptor protein NLRP3, adapter protein ASC, and inflammatory protease caspase …

ABSTRACT Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …

The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials
testing exosomes for diagnostic and therapeutic applications are generating remarkable …