The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …

The combination of obesity and hypertension is associated with high morbidity and mortality
because it leads to cardiovascular and kidney disease. Potential mechanisms linking …

Arterial aging engages a plethora of key signalling pathways that act in concert to induce
vascular smooth muscle cell (VSMC) phenotypic changes leading to vascular degeneration …

Obesity is an emerging pandemic driven by consumption of a diet rich in fat and highly
refined carbohydrates (a Western diet) and a sedentary lifestyle in both children and adults …

In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …

Obese individuals frequently develop hypertension, which is for an important part
attributable to renin-angiotensin-aldosterone system (RAAS) overactivity. This review …

Abstract Purpose of Review To update and review novel insights into the mechanisms,
measurements, and therapeutic approaches to arterial stiffness. Recent Findings Arterial …

Diabetic kidney disease (DKD) develops in∼ 40% of patients with diabetes and is the most
common cause of chronic kidney disease (CKD) worldwide. Patients with CKD, especially …

Originally described as the renal aldosterone receptor that regulates sodium homeostasis, it
is now clear that mineralocorticoid receptors (MRs) are widely expressed, including in …