Molecular biology of osteosarcoma
AM Czarnecka, K Synoradzki, W Firlej, E Bartnik… - Cancers, 2020 - mdpi.com
Osteosarcoma (OS) is the most frequent primary bone cancer in children and adolescents
and the third most frequent in adults. Many inherited germline mutations are responsible for …
and the third most frequent in adults. Many inherited germline mutations are responsible for …
Molecular genetics of osteosarcoma
K Rickel, F Fang, J Tao - Bone, 2017 - Elsevier
Osteosarcoma is the predominant form of bone cancer, affecting mostly adolescents. Recent
progress made in molecular genetic studies of osteosarcoma has changed our view on the …
progress made in molecular genetic studies of osteosarcoma has changed our view on the …
Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency
M Kovac, C Blattmann, S Ribi, J Smida… - Nature …, 2015 - nature.com
Osteosarcomas are aggressive bone tumours with a high degree of genetic heterogeneity,
which has historically complicated driver gene discovery. Here we sequence exomes of 31 …
which has historically complicated driver gene discovery. Here we sequence exomes of 31 …
Genomic profiling of childhood tumor patient-derived xenograft models to enable rational clinical trial design
Accelerating cures for children with cancer remains an immediate challenge as a result of
extensive oncogenic heterogeneity between and within histologies, distinct molecular …
extensive oncogenic heterogeneity between and within histologies, distinct molecular …
Somatic TP53 mutations in the era of genome sequencing
P Hainaut, GP Pfeifer - Cold Spring …, 2016 - perspectivesinmedicine.cshlp.org
Amid the complexity of genetic alterations in human cancer, TP53 mutation appears as an
almost invariant component, representing by far the most frequent genetic alteration overall …
almost invariant component, representing by far the most frequent genetic alteration overall …
Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group
Patients who are diagnosed with osteosarcoma (OS) today receive the same therapy that
patients have received over the last 4 decades. Extensive efforts to identify more effective or …
patients have received over the last 4 decades. Extensive efforts to identify more effective or …
TP53 in bone and soft tissue sarcomas
Genomic and functional study of existing and emerging sarcoma targets, such as fusion
proteins, chromosomal aberrations, reduced tumor suppressor activity, and oncogenic …
proteins, chromosomal aberrations, reduced tumor suppressor activity, and oncogenic …
Disruption of the TP53 locus in osteosarcoma leads to TP53 promoter gene fusions and restoration of parts of the TP53 signalling pathway
KH Saba, V Difilippo, M Kovac… - The Journal of …, 2024 - Wiley Online Library
TP53 is the most frequently mutated gene in human cancer. This gene shows not only loss‐
of‐function mutations but also recurrent missense mutations with gain‐of‐function activity …
of‐function mutations but also recurrent missense mutations with gain‐of‐function activity …
Clinical genomic sequencing of pediatric and adult osteosarcoma reveals distinct molecular subsets with potentially targetable alterations
Purpose: Although multimodal chemotherapy has improved outcomes for patients with
osteosarcoma, the prognosis for patients who present with metastatic and/or recurrent …
osteosarcoma, the prognosis for patients who present with metastatic and/or recurrent …
Risk factors for development of canine and human osteosarcoma: a comparative review
Osteosarcoma is the most common primary tumor of bone. Osteosarcomas are rare in
humans, but occur more commonly in dogs. A comparative approach to studying …
humans, but occur more commonly in dogs. A comparative approach to studying …