Genetic risk scores for diabetes diagnosis and precision medicine
During the last decade, there have been substantial advances in the identification and
characterization of DNA sequence variants associated with individual predisposition to type …
characterization of DNA sequence variants associated with individual predisposition to type …
A global overview of precision medicine in type 2 diabetes
The detailed characterization of human biology and behaviors is now possible at scale
owing to innovations in biomarkers, bioimaging, and wearable technologies;“big data” from …
owing to innovations in biomarkers, bioimaging, and wearable technologies;“big data” from …
Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
Mendelian randomisation uses genetic variation as a natural experiment to investigate the
causal relations between potentially modifiable risk factors and health outcomes in …
causal relations between potentially modifiable risk factors and health outcomes in …
Gut microbiome composition is predictive of incident type 2 diabetes in a population cohort of 5,572 Finnish adults
OBJECTIVE To examine the previously unknown long-term association between gut
microbiome composition and incident type 2 diabetes in a representative population cohort …
microbiome composition and incident type 2 diabetes in a representative population cohort …
Type 2 diabetes and hypertension: a study on bidirectional causality
Rationale: In observational studies, type 2 diabetes mellitus (T2D) has been associated with
an increased risk of hypertension, and vice versa; however, the causality between these …
an increased risk of hypertension, and vice versa; however, the causality between these …
Making the most of clumping and thresholding for polygenic scores
Polygenic prediction has the potential to contribute to precision medicine. Clumping and
thresholding (C+ T) is a widely used method to derive polygenic scores. When using C+ T …
thresholding (C+ T) is a widely used method to derive polygenic scores. When using C+ T …
[HTML][HTML] Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study
A Wesolowska-Andersen, CA Brorsson, R Bizzotto… - Cell Reports …, 2022 - cell.com
The presentation and underlying pathophysiology of type 2 diabetes (T2D) is complex and
heterogeneous. Recent studies attempted to stratify T2D into distinct subgroups using data …
heterogeneous. Recent studies attempted to stratify T2D into distinct subgroups using data …
Interactions between enhanced polygenic risk scores and lifestyle for cardiovascular disease, diabetes, and lipid levels
Background: Both lifestyle and genetic factors confer risk for cardiovascular diseases, type 2
diabetes, and dyslipidemia. However, the interactions between these 2 groups of risk factors …
diabetes, and dyslipidemia. However, the interactions between these 2 groups of risk factors …
TIGER: The gene expression regulatory variation landscape of human pancreatic islets
Genome-wide association studies (GWASs) identified hundreds of signals associated with
type 2 diabetes (T2D). To gain insight into their underlying molecular mechanisms, we have …
type 2 diabetes (T2D). To gain insight into their underlying molecular mechanisms, we have …
First genome-wide association study of latent autoimmune diabetes in adults reveals novel insights linking immune and metabolic diabetes
OBJECTIVE Latent autoimmune diabetes in adults (LADA) shares clinical features with both
type 1 and type 2 diabetes; however, there is ongoing debate regarding the precise …
type 1 and type 2 diabetes; however, there is ongoing debate regarding the precise …