First recognized as a major determinant in lipoprotein metabolism and cardiovascular
disease, apolipoprotein (apo) E has emerged as an important molecule in several biological …

Amyloid β-peptide [Aβ (1–42)] is central to the pathogenesis of Alzheimer's disease (AD),
and the AD brain is under intense oxidative stress, including membrane lipid peroxidation …

The premier single-volume reference in the field of anesthesia, Clinical Anesthesia is now in
its Sixth Edition, with thoroughly updated coverage, a new full-color design, and a revamped …

One of the major neuropathological findings in the brains of individuals with Alzheimer's
disease (AD) is a loss of synaptic contacts in both the neocortex and hippocampus. Here we …

Inheritance of the apoE4 allele (ε4) increases the risk of developing Alzheimer's disease;
however, the mechanisms underlying this association remain elusive. Recent data suggest …

Ischaemic stroke can be caused by a number of monogenic disorders, and in such cases
stroke is frequently part of a multisystem disorder. Cerebral autosomal dominant arteriopathy …

This paper presents a comprehensive assessment of sensorimotor deficits in the mouse
after focal ischaemia induced by occlusion of the middle cerebral artery. Twenty four hours …

Apolipoprotein (apo) E isoforms are key determinants of susceptibility to Alzheimer's
disease. The apoE4 isoform is the major known genetic risk factor for this disease and is …

Apolipoprotein E plays an important role in recovery from acute brain injury and risk of
developing Alzheimer's disease. We demonstrate that biologically relevant concentrations of …

Apolipoprotein E (apoE) is a 34-kDa glycoprotein involved in lipoprotein transport through
interaction with the low-density lipoprotein receptor and related receptors. Recently, it has …