Kruppel-associated box zinc-finger proteins (KRAB-ZFPs) make up the largest family of
transcription factors in humans. These proteins emerged in the last common ancestor of …

Genetically encoded tools for the regulation of endogenous molecules (RNA, DNA elements
and protein) are needed to study and control biological processes with minimal interference …

Zinc is one of the most important biologically active metals. Ten per cent of the human
genome is thought to encode a zinc binding protein and its uses encompass catalysis …

Cornea, a dome-shaped and transparent front part of the eye, affords 2/3rd refraction and
barrier functions. Globally, corneal diseases are the leading cause of vision impairment …

Novel methods and compositions for altering target nucleic acid (eg, DNA eg, genomic DNA)
sequences are provided. Fusion proteins including one or more DNA binding domains and …

Heavy metal stress (HMS) is one of the most destructive abiotic stresses which seriously
affects the growth and development of plants. Recent studies have shown significant …

锌指核酸酶(ZFN) 由锌指蛋白(ZFP) 结构域和Fok I 核酸内切酶的切割结构域人工融合而成,
是近年来发展起来的一种可用于基因组定点改造的分子工具. ZFN 可识别并结合特定的DNA …

InterMetalDB is a free-of-charge database and browser of intermolecular metal binding sites
that are present on the interfaces of macromolecules forming larger assemblies based on …

We report here the construction of engineered endonuclease database
(EENdb)(http://eendb. zfgenetics. org/), a searchable database and knowledge base for …

Clear evidence has shown that metal ions strongly connect and delicately tune the dynamic
homeostasis in living bodies. They have been proved to be associated with protein structure …