The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions

V Carlini, DM Noonan, E Abdalalem, D Goletti… - Frontiers in …, 2023 - frontiersin.org
Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating
inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory …

Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID

TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …

Engineering cells for cancer therapy

P Liu, Q Hu - Accounts of Chemical Research, 2024 - ACS Publications
Conspectus Cells, particularly living cells, serve as natural carriers of bioactive substances.
Their inherent low immunogenicity and multifunctionality have garnered significant attention …

Immunotherapy of multiple myeloma: current status as prologue to the future

HN Abramson - International Journal of Molecular Sciences, 2023 - mdpi.com
The landscape of therapeutic measures to treat multiple myeloma has undergone a seismic
shift since the dawn of the current century. This has been driven largely by the introduction of …

Mast cells in the autonomic nervous system and potential role in disorders with dysautonomia and neuroinflammation

TC Theoharides, A Twahir, D Kempuraj - Annals of Allergy, Asthma & …, 2024 - Elsevier
Mast cells (MC) are ubiquitous in the body, and they are critical for not only in allergic
diseases but also in immunity and inflammation, including having potential involvement in …

The multifaceted immunology of cytokine storm syndrome

PY Lee, RQ Cron - The Journal of Immunology, 2023 - journals.aai.org
Cytokine storm syndromes (CSSs) are potentially fatal hyperinflammatory states that share
the underpinnings of persistent immune cell activation and uninhibited cytokine production …

NLRP3 Inflammasome Involvement in Heart, Liver, and Lung Diseases—A Lesson from Cytokine Storm Syndrome

C Napodano, V Carnazzo, V Basile, K Pocino… - International Journal of …, 2023 - mdpi.com
Inflammation and inflammasomes have been proposed as important regulators of the host–
microorganism interaction, playing a key role in morbidity and mortality due to the …

[HTML][HTML] Nanoparticles and cytokine response

M Nasrullah, DN Meenakshi Sundaram… - … in Bioengineering and …, 2023 - frontiersin.org
Synthetic nanoparticles (NPs) are non-viral equivalents of viral gene delivery systems that
are actively explored to deliver a spectrum of nucleic acids for diverse range of therapies …

Gene therapy for cardiac diseases: methods, challenges, and future directions

L Grisorio, R Bongianino, M Gianeselli… - Cardiovascular …, 2024 - academic.oup.com
Gene therapy is advancing at an unprecedented pace, and the recent success of clinical
trials reinforces optimism and trust among the scientific community. Recently, the cardiac …

Vagus nerve SARS‐CoV‐2 infection and inflammatory reflex dysfunction: Is there a causal relationship?

U Andersson, KJ Tracey - Journal of Internal Medicine, 2024 - Wiley Online Library
Autonomic dysfunction is a clinical hallmark of infection caused by SARS‐CoV‐2, but the
underlying mechanisms are unknown. The vagus nerve inflammatory reflex is an important …