Psychostimulants, including amphetamines and methylphenidate, are first-line
pharmacotherapies for individuals with attention-deficit/hyperactivity disorder (ADHD). This …

For several decades, addiction has come to be viewed as a disorder of the dopamine
neurotransmitter system; however, this view has not led to new treatments. In this Opinion …

Stress has long been suggested to be an important correlate of uncontrolled drinking and
relapse. An important hormonal response system to stress—the hypothalamic–pituitary …

Stress is a well‐known risk factor in the development of addiction and in addiction relapse
vulnerability. A series of population‐based and epidemiological studies have identified …

In this review, we detail the clinical evidence supporting the role of psychological and
physiological stress in instrumental motivation for alcohol consumption during the …

In some patients with major depressive disorder (MDD), individual illness characteristics
appear consistent with those of a neuroprogressive illness. Features of neuroprogression …

Multiple sources of evidence support a role for diminished dopaminergic neurotrans-mission
in major depression. The physiological alterations underlying reduced dopa-mine (DA) …

There are no specific structural neuropathological hallmarks found in the brain of mood
disorders. Instead, there are molecular, functional and structural alterations reported in many …

Research on child and adolescent mental health problems has burgeoned since the
inaugural issue of Development and Psychopathology was published in 1989. In the quarter …

Evidence that childhood adversities are risk factors for psychosis has accumulated rapidly.
Research into the mechanisms underlying these relationships has focused, productively, on …