Neurosteroidogenesis today: novel targets for neuroactive steroid synthesis and action and their relevance for translational research
Neuroactive steroids are endogenous neuromodulators synthesised in the brain that rapidly
alter neuronal excitability by binding to membrane receptors, in addition to the regulation of …
alter neuronal excitability by binding to membrane receptors, in addition to the regulation of …
Translocator protein 18 kDa (TSPO): an old protein with new functions?
Translocator protein 18 kDa (TSPO) was previously known as the peripheral
benzodiazepine receptor (PBR) in eukaryotes, where it is mainly localized to the …
benzodiazepine receptor (PBR) in eukaryotes, where it is mainly localized to the …
Translocator protein-mediated pharmacology of cholesterol transport and steroidogenesis
Steroidogenesis begins with cholesterol transfer into mitochondria through the
transduceosome, a complex composed of cytosolic proteins that include steroidogenesis …
transduceosome, a complex composed of cytosolic proteins that include steroidogenesis …
TSPO protein binding partners in bacteria, animals, and plants
C Hiser, BL Montgomery, S Ferguson-Miller - Journal of Bioenergetics and …, 2021 - Springer
The ancient membrane protein TSPO is phylogenetically widespread from archaea and
bacteria to insects, vertebrates, plants, and fungi. TSPO's primary amino acid sequence is …
bacteria to insects, vertebrates, plants, and fungi. TSPO's primary amino acid sequence is …
TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria
J Gatliff, M Campanella - Biochemical Journal, 2016 - portlandpress.com
The 18-kDa translocator protein (TSPO) localizes in the outer mitochondrial membrane
(OMM) of cells and is readily up-regulated under various pathological conditions such as …
(OMM) of cells and is readily up-regulated under various pathological conditions such as …
Translocator protein in the rise and fall of central nervous system neurons
Translocator protein (TSPO), a 18 kDa protein found in the outer mitochondrial membrane,
has historically been associated with the transport of cholesterol in highly steroidogenic …
has historically been associated with the transport of cholesterol in highly steroidogenic …
Collision induced unfolding classifies ligands bound to the integral membrane translocator protein
Membrane proteins represent most current therapeutic targets, yet remain understudied due
to their insolubility in aqueous solvents and generally low yields during purification and …
to their insolubility in aqueous solvents and generally low yields during purification and …
Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male
AM Barron, B Ji, S Kito, T Suhara… - Biochemical …, 2018 - portlandpress.com
The translocator protein (TSPO) has been proposed to act as a key component in a complex
important for mitochondrial cholesterol importation, which is the rate-limiting step in steroid …
important for mitochondrial cholesterol importation, which is the rate-limiting step in steroid …
Regulation of anxiety and depression by mitochondrial translocator protein-mediated steroidogenesis: the role of neurons
Pharmacological studies have implicated the translocator protein (TSPO) in the regulation of
complex behaviors including anxiety and depression, effects thought to be mediated by …
complex behaviors including anxiety and depression, effects thought to be mediated by …
Phenibut (4‐amino‐3‐phenyl‐butyric acid): Availability, prevalence of use, desired effects and acute toxicity
Abstract Introduction and Aims There has been a global increase in the availability and use
of novel psychoactive substances (NPS) over the last decade. Phenibut (β‐phenyl‐γ …
of novel psychoactive substances (NPS) over the last decade. Phenibut (β‐phenyl‐γ …