Protein ADP-ribosylation is essential for the regulation of several cellular pathways,
enabling dynamic responses to diverse pathophysiological conditions. It is modulated …

Neurovascular dysfunction, as an integral part of Alzheimer's disease, may have an
important influence on the onset and progression of chronic neurodegenerative processes …

Poly (ADP-ribosyl) ation regulates numerous cellular processes like genome maintenance
and cell death, thus providing protective functions but also contributing to several …

Alzheimer's disease (AD) and cerebrovascular diseases share common vascular risk factors
that have disastrous effects on cerebrovascular regulation. Endothelial cells, lining inner …

The oncofetal mRNA-binding protein, IMP1 or insulin-like growth factor-2 mRNA-binding
protein 2 (IGF2BP1), binds to and stabilizes c-Myc, β-TrCP1, and other oncogenic mRNAs …

While poly (ADP-ribosyl) ation (PARylation) plays an important role in DNA repair, the role of
dePARylation in DNA repair remains elusive. Here, we report that a novel small molecule …

Sirtuin enzymes comprise a unique class of NAD+-dependent protein deacetylases.
Although structures of many sirtuin complexes have been determined, structural resolution …

Abstract Poly (ADP-ribose) glycohydrolase (PARG) is the primary enzyme that catalyzes the
hydrolysis of poly (ADP-ribose)(PAR), an essential biopolymer that is synthesized by poly …

Chemoresistance contributes to the majority of deaths in women with ovarian cancer (OC).
Altered DNA repair and metabolic signaling is implicated in mediating therapeutic …

The two estrogen receptor (ER) subforms, ERα and ERβ, are capable of forming DNA-
binding homodimers and heterodimers. Although binding to DNA is thought to stabilize ER …