Epithelial–mesenchymal transition in organ fibrosis development: current understanding and treatment strategies

L Liu, Q Sun, F Davis, J Mao, H Zhao, D Ma - Burns & Trauma, 2022 - academic.oup.com
Organ fibrosis is a process in which cellular homeostasis is disrupted and extracellular
matrix is excessively deposited. Fibrosis can lead to vital organ failure and there are no …

Nrf2/HO-1 as a therapeutic target in renal fibrosis

EHM Hassanein, IM Ibrahim, EK Abd-Alhameed… - Life Sciences, 2023 - Elsevier
Chronic kidney disease (CKD) is one of the most prevalent chronic diseases and affects
between 10 and 14% of the world's population. The World Health Organization estimates …

Network pharmacology-based analysis on bioactive anti-diabetic compounds in Potentilla discolor bunge

N Wang, F Zhu, M Shen, L Qiu, M Tang, H Xia… - Journal of …, 2019 - Elsevier
Abstract Ethnopharmacological relevance Potentilla discolor Bunge (PDB) is a commonly
used herbal for alleviating diabetes mellitus and its complications. Although accumulating …

Esophageal epithelial cells acquire functional characteristics of activated myofibroblasts after undergoing an epithelial to mesenchymal transition

AB Muir, K Dods, Y Noah, S Toltzis… - Experimental cell …, 2015 - Elsevier
Abstract Background and Aims Eosinophilic esophagitis (EoE) is an allergic inflammatory
disease that leads to esophageal fibrosis and stricture. We have recently shown that in EoE …

[HTML][HTML] Renal damaging effect elicited by bicalutamide therapy uncovered multiple action mechanisms as evidenced by the cell model

CC Peng, CY Chen, CR Chen, CJ Chen, KH Shen… - Scientific reports, 2019 - nature.com
Bicalutamide (Bic) is frequently used in androgen deprivation therapy (ADT) for treating
prostate cancer. ADT-induced hypogonadism was reported to have the potential to lead to …

[HTML][HTML] Reference genes for mesangial cell and podocyte qPCR gene expression studies under high-glucose and renin-angiotensin-system blocker conditions

ND Hosni, AC Anauate, MA Boim - PLoS One, 2021 - journals.plos.org
Background Real-time PCR remains currently the gold standard method for gene
expression studies. Identification of the best reference gene is a key point in performing high …

[HTML][HTML] The missing link: studying the alternative TGF-β pathway provides a unifying theory for different components of diabetic nephropathy

X Zheng, V Bhalla - Diabetes, 2015 - ncbi.nlm.nih.gov
Diabetic nephropathy (DN) contributes to nearly 50% of chronic kidney disease and end-
stage renal disease cases in the United States (1). Despite clinical trials that have affirmed …

[PDF][PDF] Role of Angiotensin II and Renal Nerves on TGF-β/Smad Pathway in Diabetic Nephropathy Rat Model

E KOLIEB, FA MOHAMMAD, SM YOUSEF, SE KASSAB - researchgate.net
Abstract Background: Renal nerves and Renin-Angiotensin Aldosterone System (RAAS) are
involved in the early renal pathological changes occurring during the development of …

[引用][C] 妊娠期糖尿病孕妇血清HSP70 水平升高并促进胎盘间质纤维化

胡丽芳, 黄文珍, 刘彤 - 收藏, 2018