The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

Programmable nucleases allow defined alterations in the genome with ease-of-use,
efficiency, and specificity. Their availability has led to accurate and widespread genome …

Gene correction in human long-term hematopoietic stem cells (LT-HSCs) could be an
effective therapy for monogenic diseases of the blood and immune system. Here we …

The molecular and cellular signals that guide T-cell development from hematopoietic stem
and progenitor cells (HSPCs) remain poorly understood. The thymic microenvironment …

Mutations of the Janus family kinase JAK3 gene cause severe combined immunodeficiency
(SCID). JAK3 deficiency in humans is characterized by the absence of circulating T cells and …

The ability to replace defective cells in an airway with cells that can engraft, integrate, and
restore a functional epithelium could potentially cure a number of lung diseases. Progress …

During the last years, several strategies have been made to obtain mature erythrocytes or
red blood cells (RBC) from the bone marrow or umbilical cord blood (UCB). However, UCB …

The differentiation of human induced pluripotent stem cells (hiPSCs) into T and natural killer
(NK) lymphocytes opens novel possibilities for developmental studies of immune cells and …

Inherited blood disorders comprise a large spectrum of diseases due to germline mutations
in genes with key function in the hematopoietic system; they include immunodeficiencies …

Recent advances in genome editing with programmable nucleases have opened up new
avenues for multiple applications, from basic research to clinical therapy. The ease of use of …