This article provides minimum requirements for having confidence in the accuracy of
EC50/IC50 estimates. Two definitions of EC50/IC50s are considered: relative and absolute …

Particulate Matter (PM) air pollution is one of the major concerns for environment and health.
Understanding the heterogeneity and complexity of fine and ultrafine PM is a fundamental …

Adaptive designs are increasingly developed and used to improve all phases of clinical
trials and in biomedical studies in various ways to address different statistical issues. We first …

Highlights•Quantitative HTS has much potential to advance drug discovery and toxicity
testing.•Nonlinear modeling of concentration–response data in suboptimal designs is …

Context: We noticed paucity in exploiting solutol-based lipid nanocapsules in statins
formulations though they carry all favorable properties that are needed for cancer passive …

Studies of chronic lymphocytic leukemia (CLL) have yielded substantial progress, however a
lack of immortalized cell lines representative of the primary disease has hampered a full …

Protein synthesis is a powerful therapeutic target in leukemias and other cancers, but few
pharmacologically viable agents are available that affect this process directly. The plant …

This study introduces the Hill model for modelling sorption kinetics and illustrates its efficacy
using formal model selection procedures. Although the coefficient of determination (R 2) …

One of the main criticisms of optimal experimental designs is that they tend not to adequately
meet the practical needs of the experimenter. For example, optimal designs for estimation of …

This study investigates the effect of unsteady wind on sand transport in a wind tunnel using
sinusoidally varying wind velocity to represent the unsteady wind. By comparing sand …