Pyrrolizidine alkaloids: occurrence, biology, and chemical synthesis

J Robertson, K Stevens - Natural Product Reports, 2017 - pubs.rsc.org
Covering: 2013 up to the end of 2015 This review covers the isolation and structure of new
pyrrolizidines; pyrrolizidine biosynthesis; biological activity, including the occurrence of …

Chemical language and warfare of bacterial natural products in bacteria–nematode–insect interactions

YM Shi, HB Bode - Natural product reports, 2018 - pubs.rsc.org
Covering: up to November 2017 Organismic interaction is one of the fundamental principles
for survival in any ecosystem. Today, numerous examples show the interaction between …

Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus

NJ Tobias, H Wolff, B Djahanschiri, F Grundmann… - Nature …, 2017 - nature.com
Xenorhabdus and Photorhabdus species dedicate a large amount of resources to the
production of specialized metabolites derived from non-ribosomal peptide synthetase …

Dehydroamino acid residues in bioactive natural products

S Wang, K Wu, YJ Tang, H Deng - Natural Product Reports, 2024 - pubs.rsc.org
Covering: 2000 to up to 2023 α, β-Dehydroamino acids (dhAAs) are unsaturated
nonproteinogenic amino acids found in a wide array of naturally occurring peptidyl …

[HTML][HTML] Complex peptide natural products: biosynthetic principles, challenges and opportunities for pathway engineering

SL Wenski, S Thiengmag, EJN Helfrich - Synthetic and systems …, 2022 - Elsevier
Complex peptide natural products exhibit diverse biological functions and a wide range of
physico-chemical properties. As a result, many peptides have entered the clinics for various …

Direct pathway cloning (DiPaC) to unlock natural product biosynthetic potential

C Greunke, ER Duell, PM D'Agostino, A Glöckle… - Metabolic …, 2018 - Elsevier
Specialized metabolites from bacteria are an important source of inspiration for drug
development. The genes required for the biosynthesis of such metabolites in bacteria are …

Native roles of Baeyer–Villiger monooxygenases in the microbial metabolism of natural compounds

C Tolmie, MS Smit, DJ Opperman - Natural product reports, 2019 - pubs.rsc.org
Covering: up to end of June 2018 Baeyer–Villiger monooxygenases (BVMOs) are flavin-
dependent enzymes that catalyse the oxidation of ketones and cyclic ketones to esters and …

The enzymology of organic transformations: a survey of name reactions in biological systems

CI Lin, RM McCarty, H Liu - Angewandte Chemie International …, 2017 - Wiley Online Library
Chemical reactions that are named in honor of their true, or at least perceived, discoverers
are known as “name reactions”. This Review is a collection of biological representatives of …

Pyrrolizidine alkaloids—Pros and cons for pharmaceutical and medical applications

K Jayawickreme, D Świstak, E Ozimek… - International Journal of …, 2023 - mdpi.com
Heterocyclic organic compounds named pyrrolizidine alkaloids (PAs) belong to a group of
alkaloids and are synthesized by either plants or microorganisms. Therefore, they are …

Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase

S Wang, WDG Brittain, Q Zhang, Z Lu, MH Tong… - Nature …, 2022 - nature.com
Abstract Non-Ribosomal Peptide Synthetases (NRPSs) assemble a diverse range of natural
products with important applications in both medicine and agriculture. They consist of …