APT‐weighted MRI: techniques, current neuro applications, and challenging issues

J Zhou, HY Heo, L Knutsson… - Journal of Magnetic …, 2019 - Wiley Online Library
Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that
generates image contrast based predominantly on the amide protons in mobile cellular …

Mitochondrial dysfunction in heart failure with preserved ejection fraction

AA Kumar, DP Kelly, JA Chirinos - Circulation, 2019 - Am Heart Assoc
Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with an
increasingly recognized heterogeneity in pathophysiology. Exercise intolerance is the …

An overview of CEST MRI for non-MR physicists

B Wu, G Warnock, M Zaiss, C Lin, M Chen, Z Zhou… - EJNMMI physics, 2016 - Springer
The search for novel image contrasts has been a major driving force in the magnetic
resonance (MR) research community, in order to gain further information on the body's …

Dynamic glucose-enhanced (DGE) MRI: translation to human scanning and first results in glioma patients

X Xu, NN Yadav, L Knutsson, J Hua, R Kalyani… - …, 2015 - pmc.ncbi.nlm.nih.gov
Recent animal studies have shown that d-glucose is a potential biodegradable magnetic
resonance imaging (MRI) contrast agent for imaging glucose uptake in tumors. We show …

Identifying recurrent malignant glioma after treatment using amide proton transfer-weighted MR imaging: a validation study with image-guided stereotactic biopsy

S Jiang, CG Eberhart, M Lim, HY Heo, Y Zhang… - Clinical Cancer …, 2019 - AACR
Purpose: To quantify the accuracy of amide proton transfer-weighted (APTw) MRI for
identifying active glioma after treatment via radiographically guided stereotactic tissue …

Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder

S Nisar, M Haris - Molecular psychiatry, 2023 - nature.com
Autism-spectrum disorders (ASDs) are developmental disabilities that manifest in early
childhood and are characterized by qualitative abnormalities in social behaviors …

Friend or foe? Defining the role of glutamate in aging and Alzheimer's disease

MKF Cox, ER Hascup, A Bartke, KN Hascup - Frontiers in Aging, 2022 - frontiersin.org
Aging is a naturally occurring decline of physiological processes and biological pathways
that affects both the structural and functional integrity of the body and brain. These …

Review and consensus recommendations on clinical APT‐weighted imaging approaches at 3T: application to brain tumors

J Zhou, M Zaiss, L Knutsson, PZ Sun… - Magnetic resonance …, 2022 - Wiley Online Library
Amide proton transfer‐weighted (APTw) MR imaging shows promise as a biomarker of brain
tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially …

Imaging blood-brain barrier dysfunction: A state-of-the-art review from a clinical perspective

P Moyaert, BE Padrela, CA Morgan, J Petr… - Frontiers in aging …, 2023 - frontiersin.org
The blood-brain barrier (BBB) consists of specialized cells that tightly regulate the in-and
outflow of molecules from the blood to brain parenchyma, protecting the brain's …

Seizures and epilepsy in patients with ischaemic stroke

JP Zöllner, FC Schmitt, F Rosenow, K Kohlhase… - … Research and Practice, 2021 - Springer
Background With the increased efficacy of stroke treatments, diagnosis and specific
treatment needs of patients with post-stroke seizures (PSS) and post-stroke epilepsy have …