Regulated cell death mediated by dedicated molecular machines, known as programmed
cell death, plays important roles in health and disease. Apoptosis, necroptosis and …

The death domain (DD) superfamily comprising the death domain (DD) subfamily, the death
effector domain (DED) subfamily, the caspase recruitment domain (CARD) subfamily, and …

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a critical regulator of cell
death and inflammation, but its relevance for human disease pathogenesis remains elusive …

Apoptosis is a form of programmed cell death that is controlled by aspartate-specific cysteine
proteases called caspases. In the immune system, apoptosis counters the proliferation of …

Across clinical trials, T cell expansion and persistence following adoptive cell transfer (ACT)
have correlated with superior patient outcomes. Herein, we undertook a pan-cancer analysis …

Heterozygous mutations encoding abnormal forms of the death receptor Fas dominantly
interfere with Fas-induced lymphocyte apoptosis in human autoimmune lymphoproliferative …

Lymphomas were studied in kindreds with autoimmune lymphoproliferative syndrome
(ALPS; Canale-Smith syndrome), a disorder of lymphocyte homeostasis usually associated …

Autoimmune lymphoproliferative syndrome (ALPS) presents in childhood with nonmalignant
lymphadenopathy and splenomegaly associated with a characteristic expansion of mature …

The death-inducing signaling complex (DISC) formed by the death receptor Fas, the adaptor
protein FADD and caspase-8 mediates the extrinsic apoptotic program. Mutations in Fas that …

The mouse protein Qa-1 (HLA-E in humans) is essential for immunological protection and
immune regulation. Although Qa-1 has been linked to CD8 T cell–dependent suppression …