Monoclonal antibodies (mAbs) have become one of the most important classes of
biopharmaceutical products, and they continue to dominate the universe of …

The MET oncogene encodes an unconventional receptor tyrosine kinase with pleiotropic
functions: it initiates and sustains neoplastic transformation when genetically altered …

Antibodies as ideal therapeutic and diagnostic molecules are among the top-selling drugs
providing considerable efficacy in disease treatment, especially in cancer therapy …

The role of aberrant hepatocyte growth factor receptor (c-MET, also known as tyrosine-
protein kinase MET)/hepatocyte growth factor (HGF) signaling in cancer progression and …

Dysregulated receptor tyrosine kinase signaling in human cancer cells leads to tumor
progression, invasion and metastasis. The receptor tyrosine kinase cMET is frequently …

Tumor biomarkers, the substances which are produced by tumors or the body's responses to
tumors during tumorigenesis and progression, have been demonstrated to possess critical …

Epidermal growth factor receptor (EGFR) mutant non-small cell lung cancers acquire
resistance to EGFR tyrosine kinase inhibitors through multiple mechanisms including c-Met …

Simple Summary The MET gene encodes a receptor critical for cell growth and repair. It
plays diverse roles in processes like organ development, wound healing, and blood vessel …

The abnormal stimulation of the multiple signal transduction pathways downstream of the
receptor tyrosine kinase mesenchymal-epithelial transition factor (cMET) promotes cellular …

Papillary renal cell carcinoma (PRCC) is a subtype of renal cell carcinoma (RCC)
accounting for approximately 15–20% of cases and further divided into Type 1 and Type 2 …