BCG immunotherapy is the gold-standard treatment for non-muscle-invasive bladder cancer
at high risk of recurrence or progression. Preclinical and clinical studies have revealed that a …

Neutrophils were among the first leukocytes described and visualized by early
immunologists. Prominent effector functions during infection and sterile inflammation …

Trained innate immunity, induced via modulation of mature myeloid cells or their bone
marrow progenitors, mediates sustained increased responsiveness to secondary …

Infiltrating inflammatory cells are highly prevalent within the tumor microenvironment and
mediate many processes associated with tumor progression; however, the contribution of …

Neutrophils are the most abundant leukocytes in blood and are considered to be the first line
of defense during inflammation and infections. In addition, neutrophils are also found …

Abstract Bacillus Calmette–Guérin (BCG) has been used to treat non-muscle-invasive
bladder cancer for more than 30 years. It is one of the most successful biotherapies for …

The importance of tumor associated neutrophils (TANs) in cancer development is in the
meantime well established. Numerous of clinical data document the adverse prognostic …

The tumor microenvironment is a complex framework, in which myeloid cells play important
roles in sculpting cancer development from tumor initiation to metastasis. Immune cells are …

TGF-β blockade significantly slows tumor growth through many mechanisms, including
activation of CD8+ T cells and macrophages. Here, we show that TGF-β blockade also …

The principle of trained immunity represents innate immune memory due to sustained,
mainly epigenetic, changes triggered by endogenous or exogenous stimuli in bone marrow …