Simple Summary Poly (ADP-ribose) polymerase 1 (PARP1) is perhaps the most studied
member of the PARP superfamily and participates in numerous cellular processes. PARP1 …

Understanding the function of eukaryotic genomes, including the human genome, is
undoubtedly one of the major scientific challenges of the 21st century. The cornerstone of …

Energy generation in the brain to ameliorate energy deficit in migraine leads to oxidative
stress as it is associated with reactive oxygen species (ROS) that may damage DNA and …

Human poly (ADP)-ribose polymerase-1 (PARP1) is a global regulator of various cellular
processes, from DNA repair to gene expression. The underlying mechanism of PARP1 …

The functioning of the eukaryotic cell genome is mediated by sophisticated protein-nucleic-
acid complexes, whose minimal structural unit is the nucleosome. After the damage to …

The natural polyphenol resveratrol is a biologically active compound that interacts with DNA
and affects the activity of some nuclear enzymes. Its effect on the interaction between …

Abstract Poly (ADP)-ribose polymerase 1 (PARP1) is an abundant nuclear protein well-
known for its role in DNA repair yet also participates in DNA replication, transcription, and co …

Poly (ADP-ribose) polymerase-1 (PARP1) binds DNA lesions to catalyse poly (ADP-ribosyl)
ation (PARylation) using NAD+ as a substrate. PARP1 plays multiple roles in cellular …

Reaction of (ADP-ribosyl) ation catalyzed by DNA-dependent proteins of the poly (ADP-
ribose) polymerase (PARP) family, PARP1, PARP2, and PARP3, comprises the cellular …

Abstract Poly (ADP-ribose)(PAR) is a negatively charged polymer, linear or branched, that
consists of ADP-ribose monomers. PAR is synthesized by poly (ADP-ribose) polymerase …