The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

The physical characteristics of tumours are intricately linked to the tumour phenotype and
difficulties during treatment. Many factors contribute to the increased stiffness of tumours; …

Cancer has been characterized as a genetic disease, associated with mutations that cause
pathological alterations of the cell cycle, adhesion, or invasive motility. Recently, the …

From embryonic development, postnatal growth and adult homeostasis to reparative and
disease states, cells and tissues undergo constant changes in genome activity, cell fate …

Mechanobiology is a rapidly growing research area focused on how mechanical forces and
properties influence biological systems at the cell, molecular, and tissue level, and how …

The cross-talk between stem cells and their microenvironment has been shown to have a
direct impact on stem cells' decisions about proliferation, growth, migration, and …

Extracellular biophysical cues have a profound influence on a wide range of cell behaviors,
including growth, motility, differentiation, apoptosis, gene expression, adhesion, and signal …

Neuroblastoma is a solid, neuroendocrine tumor with divergent clinical behavior ranging
from asymptomatic to fatal. The diverse clinical presentations of neuroblastoma are directly …

Alterations in mechano-physiological properties of a tissue instigate cancer burdens in
parallel to common genetic and epigenetic alterations. The chronological and mechanistic …