Duchenne and Becker muscular dystrophy (DMD/BMD) comprise a spectrum of devastating
X-linked muscle wasting disease for which there is no treatment. DMD/BMD is caused by …

Duchenne muscular dystrophy is a lethal X-linked muscle disease resulting from a defect in
the muscle membrane protein dystrophin. The absence of dystrophin leads to muscle …

Many cell types of therapeutic interest, including myoblasts, exhibit reduced engraftment if
cultured prior to transplantation. This study investigated whether polymeric scaffolds that …

Nitric oxide is a short-lived intracellular and intercellular messenger. The first realisation that
nitric oxide is important in physiology occurred in 1987 when its identity with the …

Duchenne muscular dystrophy (DMD) affects young boys and is characterized by the
absence of dystrophin, a large cytoskeletal protein present in skeletal and cardiac muscle …

Debilitating muscle-disuse atrophy in aging or obesity has huge socioeconomic impact.
Since nitric oxide (NO) mediates muscle satellite cell activation and induces hypertrophy …

Duchenne muscular dystrophy (DMD) is one of the most common and severe forms of
muscular dystrophy. Oxidative myofibre content, muscle vasculature architecture and …

Satellite cell (SC) activation, mediated by nitric oxide (NO), is essential to myogenic repair,
whereas myotube function requires innervation. Semaphorin (Sema) 3A, a neuro …

Duchenne Muscular Dystrophy (DMD) is a fatal genetic muscle wasting disease with no
current cure. A prominent, yet poorly treated feature of dystrophic muscle is the …

Key points Dystrophin deficiency disrupts sarcolemmal targeting of neuronal nitric oxide
synathase, resulting in functional muscle ischaemia. Chronic treatment of dystrophic mice …