Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative
properties results in debilitating musculoskeletal disorders. Understanding the mechanisms …

The formation of skeletal muscle is a tightly regulated process that is critically modulated by
Wnt signaling. Myogenesis is dependent on the precise and dynamic integration of multiple …

Pluripotent stem cells (PSCs) are attractive regenerative therapy tools for skeletal tissues.
However, a deep understanding of skeletal development is required in order to model this …

Continuing research on the onset of skeletal myogenesis in the somite is providing new
insights into the behaviour of early myogenic progenitor cells and how signalling molecules …

Dorsal dermis and epaxial muscle have been shown to arise from the central
dermomyotome in the chick. En1 is a homeobox transcription factor gene expressed in the …

Cellular plasticity is fundamental to embryonic development. The importance of cellular
transitions in development is first apparent during gastrulation when the process of epithelial …

Wnt is a family of signaling molecules involved in embryogenesis, adult tissue repair, and
cancer. They activate canonical and noncanonical Wnt signaling cascades in target cells …

Vertebrate muscle arises sequentially from embryonic, fetal, and adult myoblasts. Although
functionally distinct, it is unclear whether these myoblast classes develop from common or …

The molecular, genetic and cellular bases for skeletal muscle growth and regeneration have
been recently documented in a number of vertebrate species. These studies highlight the …

Cells anchor to substrates by binding to extracellular matrix (ECM). In addition to this
anchoring function however, cell–ECM binding is a mechanism for cells to sense their …