Lipid peroxidation involves a cascade of reactions in which production of free radicals
occurs selectively in the lipid components of cellular membranes. Polyunsaturated fatty …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

Protein SUMOylation is a critically important posttranslational protein modification that
participates in nearly all aspects of cellular physiology. In the nearly 20 years since its …

Neuropathic pain remains poorly treated for large numbers of patients, and little progress
has been made in developing novel classes of analgesics. To redress this issue, ziconotide …

Collapsin response mediator proteins (CRMPs) are a family of ubiquitously expressed,
homologous phosphoproteins best known for coordinating cytoskeletal formation and …

CRMP2, also known as DPYSL2/DRP2, Unc-33, Ulip or TUC2, is a cytosolic phosphoprotein
that mediates axon/dendrite specification and axonal growth. Mapping the CRMP2 …

Study design: This is a narrative review of the literature. Objectives: This review aims to be
useful in identifying therapeutic targets. It focuses on the molecular and biochemical …

Voltage-gated calcium ion (Ca V) channels convert neuronal activity into rapid intracellular
calcium signals to trigger a myriad of cellular responses. Their involvement in major …

Targeting proteins within the N-type voltage-gated calcium channel (CaV2. 2) complex has
proven to be an effective strategy for developing novel pain therapeutics. We describe a …

Chemotherapy-induced peripheral neuropathy (CIPN) is common in patients receiving
anticancer treatment and can affect survivability and long-term quality of life of the patient …