New insights on transition metal coordination compounds with biological active azole and nitroimidazole derivatives

R Navarro-Peñaloza, B Landeros-Rivera… - Coordination Chemistry …, 2023 - Elsevier
In this review we have selected some notable examples of azoles and nitroimidazoles and
their coordination compounds with previously reported biological effectiveness. In an effort …

Current techniques of water solubility improvement for antioxidant compounds and their correlation with its activity: molecular pharmaceutics

A Budiman, A Rusdin, DL Aulifa - Antioxidants, 2023 - mdpi.com
The aqueous solubility of a drug is important in the oral formulation because the drug can be
absorbed from intestinal sites after being dissolved in the gastrointestinal fluid, leading to its …

Simultaneous improvement of dissolution behavior and oral bioavailability of antifungal miconazole via cocrystal and salt formation

KV Drozd, AN Manin, DE Boycov, GL Perlovich - Pharmaceutics, 2022 - mdpi.com
Miconazole shows low oral bioavailability in humans due to poor aqueous solubility,
although it has demonstrated various pharmacological activities such as antifungal, anti …

Organoantimony Dihydroperoxides: Synthesis, Crystal Structures, and Hydrogen Bonding Networks

PA Egorov, DA Grishanov, AG Medvedev… - Inorganic …, 2023 - ACS Publications
Despite growing interest in the potential applications of p-block hydroperoxo complexes, the
chemistry of inorganic hydroperoxides remains largely unexplored. For instance, single …

[HTML][HTML] Influence of Solvent Polarity on the Conformer Ratio of Bicalutamide in Saturated Solutions: Insights from NOESY NMR Analysis and Quantum-Chemical …

VV Sobornova, KV Belov, MA Krestyaninov… - International Journal of …, 2024 - mdpi.com
The study presents a thorough and detailed analysis of bicalutamide's structural and
conformational properties. Quantum chemical calculations were employed to explore the …

Pharmaceutical multicomponent crystals of antifungal drugs with improved dissolution performance

KV Drozd, AN Manin, DE Boycov… - Crystal Growth & …, 2021 - ACS Publications
New multicomponent crystals of climbazole (CLB) with fumaric acid (FumAc) and
tioconazole (TCL) with oxalic (OxlAc), malonic (MlnAc), fumaric, and dl-tartaric (TartAc) acids …

Preparation and structure analysis of non-covalent interactions mediated 2D-3D supramolecular adducts from 6-methylnicotinamide and carboxylic acids

Y Wu, J Zhou, S Jin, B Liu, C Shi, D Wang - Journal of Molecular Structure, 2022 - Elsevier
methylnicotinamide was utilized to create co-crystal/salts for the first time. By introducing it
into the co-crystallization system based on different carboxylic acids of mono-to dicarboxylic …

Computational evaluation of halogen-bonded cocrystals enables prediction of their mechanochemical interconversion reactions

L Kumar, K Leko, V Nemec, D Trzybiński… - Chemical …, 2023 - pubs.rsc.org
Periodic density-functional theory (DFT) calculations were used to predict the
thermodynamic stability and the likelihood of interconversion between a series of halogen …

Supramolecular self-assembly with p-coumaric acid offers the first cocrystal for perfecting the physicochemical peculiarity and enhancing the antifungal effect of drug …

M Zhang, MY Wang, YM Yu, SS Meng, CW Yan… - …, 2023 - pubs.rsc.org
With the aim of giving prominence to the ability and dominance of phenolic acid nutrient p-
coumaric acid (TPA) towards ameliorating the medicinal properties of BCS class-IV …

Recent advances on the biological study of pharmaceutical cocrystals

Z Wang, Y Xie, M Yu, S Yang, Y Lu, G Du - Aaps Pharmscitech, 2022 - Springer
As a low-risk, low-cost, but high-reward route, cocrystallization of drugs with appropriate
coformers is applied to improve the physiochemical and biopharmaceutical properties of …