MYCN is a member of the MYC family of proto-oncogenes. It encodes a transcription factor,
MYCN, involved in the control of fundamental processes during embryonal development …

Simple Summary Neuroblastoma is one of the most diffuse and the deadliest cancer in
children. While many advances have been made in the last few decades to improve patients' …

P53 is often mutated in solid tumors, in fact, somatic changes involving the gene encoding
for p53 (TP53) have been discovered in more than 50% of human malignancies and several …

Dichloroacetate (DCA) has several therapeutic applications based on its pharmacological
property of inhibiting pyruvate dehydrogenase kinase. DCA has been used to treat inherited …

Purpose: Diffuse intrinsic pontine gliomas (DIPG) are the most severe pediatric brain tumors.
Although accepted as the standard therapeutic, radiotherapy is only efficient transiently and …

Cancer treatment with ionizing radiation (IR) is a well-established and effective clinical
method to fight different types of tumors and is a palliative treatment to cure metastatic …

Background Radioresistance is the major cause of cancer treatment failure. Additionally,
splicing dysregulation plays critical roles in tumorigenesis. However, the involvement of …

Glutathione (GSH) is one of the most important defenses against oxidative stress through the
fine-tuned regulation of redox homeostasis. Glutathione is also involved in many metabolic …

Background p53 plays a key role in the DNA repair process and response to ionising
radiation. We sought to determine the clinical phenotype of TP53 mutations and p53 …

Targeting glutamine metabolism has emerged as a potential therapeutic strategy for Myc
overexpressing cancer cells. Myc proteins contribute to an aggressive neuroblastoma …