SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection is silent or benign
in most infected individuals, but causes hypoxemic COVID-19 pneumonia in about 10% of …

Background We previously reported that impaired type I IFN activity, due to inborn errors of
TLR3-and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type …

Investigating the role of host genetic factors in COVID-19 severity and susceptibility can
inform our understanding of the underlying biological mechanisms that influence adverse …

The COVID-19 pandemic had cross-cutting impacts on planetary health, quotidian life, and
society. Mass vaccination with the current gene-based vaccines has helped control the …

Since the emergence and rapid transmission of SARS-CoV-2, numerous scientific reports
have searched for the association of host genetic variants with COVID-19, but the data are …

There is abundant epidemiological data indicating that the incidence of severe cases of
coronavirus disease (COVID-19) is significantly higher in males than females worldwide …

Rare variants affecting host defense against pathogens may be involved in COVID-19
severity, but most rare variants are not expected to have a major impact on the course of …

Predicting COVID-19 severity is difficult, and the biological pathways involved are not fully
understood. To approach this problem, we measured 4701 circulating human protein …

Although all multicellular organisms have germ line–encoded innate receptors to sense
pathogen-associated molecular patterns, vertebrates also evolved adaptive immunity based …

Recent developments in sequencing technologies, the computer and data sciences, as well
as increasingly high-throughput immunological measurements have made it possible to …