In less than 10 years, melanoma treatment has been revolutionized with the approval of
tyrosine kinase inhibitors and immune checkpoint inhibitors, which have been shown to …

Melanoma develops as a result of several genetic alterations, with UV radiation often acting
as a mutagenic risk factor. Deep knowledge of the molecular signaling pathways of different …

Melanoma is the sixth most frequent malignancy. It represents 1.7% of all cancer cases
worldwide. Many risk factors are associated with melanoma including ultraviolet radiation …

Melanoma is often considered one of the most aggressive and treatment-resistant human
cancers. It is a disease that, due to the presence of melanin pigment, was accurately …

The target of rapamycin (TOR) is a highly conserved protein kinase and a central controller
of growth. Mammalian TOR complex 2 (mTORC2) regulates AGC kinase family members …

Melanoma | New England Journal of Medicine Skip to main content The New England Journal
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Melanoma has markedly increased worldwide during the past several decades in the
Caucasian population and is responsible for 80% of skin cancer deaths. Considering that …

Emergence of castration-resistant metastatic prostate cancer is due to activation of survival
pathways, including apoptosis suppression and anoikis resistance, and increased …

Cell for cell, probably no human cancer is as aggressive as melanoma. It is among a handful
of cancers whose dimensions are reported in millimeters. Tumor thickness approaching 4 …

Malignant melanoma is the skin cancer with the most significant impact on man, carrying the
highest risk of death from metastasis. Both incidence and mortality rates continue to rise …