Despite its short history, diffraction-unlimited fluorescence microscopy techniques have
already made a substantial imprint in the biological sciences. In this review, we describe …

Fluorescence provides a mechanism for achieving contrast in biological imaging that
enables investigations of molecular structure, dynamics, and function at high spatial and …

Saturated heterocycles are found in numerous therapeutics and bioactive natural products
and are abundant in many medicinal and agrochemical compound libraries. To access new …

The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three
gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by …

The HIV-1 envelope (Env) mediates viral entry into host cells. To enable the direct imaging
of conformational dynamics within Env, we introduced fluorophores into variable regions of …

The HIV-1 envelope glycoprotein (Env) trimer mediates cell entry and is conformationally
dynamic,,,,,,–. Imaging by single-molecule fluorescence resonance energy transfer …

Argonaute proteins repress gene expression and defend against foreign nucleic acids using
short RNAs or DNAs to specify the correct target RNA or DNA sequence. We have …

The breakthroughs in single molecule spectroscopy of the last decade and the recent
advances in super resolution microscopy have boosted the popularity of cyanine dyes in …

Aminoglycosides are chemically diverse, broad-spectrum antibiotics that target functional
centers within the bacterial ribosome to impact all four principle stages (initiation, elongation …

Decoding cellular processes requires visualization of the spatial distribution and dynamic
interactions of biomolecules. It is therefore not surprising that innovations in imaging …