Structural properties of soluble peptide amphiphile micelles

A Trent, R Marullo, B Lin, M Black, M Tirrell - Soft Matter, 2011 - pubs.rsc.org
Peptide amphiphiles (PAs) self-assemble into dynamic micellar structures that provide a
multivalent display of functional peptides and are currently being developed for use in a …

Structure-based programming of lymph-node targeting in molecular vaccines

H Liu, KD Moynihan, Y Zheng, GL Szeto, AV Li… - Nature, 2014 - nature.com
In cancer patients, visual identification of sentinel lymph nodes (LNs) is achieved by the
injection of dyes that bind avidly to endogenous albumin, targeting these compounds to LNs …

Engineering janus chemoreactive nanosonosensitizers for bilaterally augmented sonodynamic and chemodynamic cancer nanotherapy

W Xu, C Dong, H Hu, X Qian, L Chang… - Advanced Functional …, 2021 - Wiley Online Library
As a non‐invasive treatment modality with high tissue‐penetration depth, ultrasound‐
triggered sonodynamic therapy (SDT) has been extensively explored and is regarded as the …

Smart pH-sensitive and temporal-controlled polymeric micelles for effective combination therapy of doxorubicin and disulfiram

X Duan, J Xiao, Q Yin, Z Zhang, H Yu, S Mao, Y Li - ACS nano, 2013 - ACS Publications
The combination of a chemotherapeutic drug with a multidrug resistance (MDR) modulator
has emerged as a promising strategy for treating MDR cancer. To ensure two drugs could be …

Supramolecular nanostructures as drug carriers

R Lin, H Cui - Current opinion in chemical engineering, 2015 - Elsevier
Highlights•Anticancer drugs could serve as part of the building units to promote molecular
assembly.•Drug amphiphiles could create discrete nanostructures with a high and fixed drug …

FRET-based analysis on the structural stability of polymeric micelles: Another key attribute beyond PEG coverage and particle size affecting the blood clearance

C Guo, H Yuan, Y Yu, Z Gao, Y Zhang, T Yin… - Journal of Controlled …, 2023 - Elsevier
Various attributes of micelles, such as PEG density and particle size, are considered to be
related to blood clearance. The structural stability of micelles is another key attribute that will …

Albumin‐Hitchhiking Drug Delivery to Tumor‐Draining Lymph Nodes Precisely Boosts Tumor‐Specific Immunity through Autophagy Modulation of Immune Cells

X Wang, D Chen, K Huang, M Li, C Zhan… - Advanced …, 2023 - Wiley Online Library
Tumor‐draining lymph nodes (TDLNs) are the first sites where tumor components reach and
dendritic cells (DCs) present tumor‐associated antigens to T cells. DCs rely on autophagy to …

NIR-II cell endocytosis-activated fluorescent probes for in vivo high-contrast bioimaging diagnostics

Y He, S Wang, P Yu, K Yan, J Ming, C Yao, Z He… - Chemical …, 2021 - pubs.rsc.org
Fluorescence probes have great potential to empower bioimaging, precision clinical
diagnostics and surgery. However, current probes are limited to in vivo high-contrast …

The role of critical micellization concentration in efficacy and toxicity of supramolecular polymers

H Su, F Wang, W Ran, W Zhang… - Proceedings of the …, 2020 - National Acad Sciences
The inception and development of supramolecular chemistry have provided a vast library of
supramolecular structures and materials for improved practice of medicine. In the context of …

Engineered plant-derived extracellular vesicles for targeted regulation and treatment of colitis-associated inflammation

SJ Kang, JH Lee, WJ Rhee - Theranostics, 2024 - pmc.ncbi.nlm.nih.gov
Rationale: Inflammatory bowel disease (IBD) is a chronic disorder characterized by
persistent inflammation of the gastrointestinal tract. Due to the elusive causes and complex …