Navigating the dementia landscape: Biomarkers and emerging therapies
The field of dementia research has witnessed significant developments in our understanding
of neurodegenerative disorders, with a particular focus on Alzheimer's disease (AD) and …
of neurodegenerative disorders, with a particular focus on Alzheimer's disease (AD) and …
Dendrimers in corneal drug delivery: recent developments and translational opportunities
Dendrimers are biocompatible organic nanomaterials with unique physicochemical
properties, making them the focus of recent research in drug delivery. The cornea of the …
properties, making them the focus of recent research in drug delivery. The cornea of the …
A Review on Tau Targeting Biomimetics Nano Formulations: Novel Approach for Targeting Alzheimer's Diseases
Central nervous system disorders are prevalent, profoundly debilitating, and poorly
managed. Developing innovative treatments for these conditions, including Alzheimer's …
managed. Developing innovative treatments for these conditions, including Alzheimer's …
Dendrimer-enabled targeted delivery attenuates glutamate excitotoxicity and improves motor function in a rabbit model of cerebral palsy
Glutamate carboxypeptidase II (GCPII), localized on the surface of astrocytes and activated
microglia, regulates extracellular glutamate concentration in the central nervous system …
microglia, regulates extracellular glutamate concentration in the central nervous system …
Inorganic Nanoparticles for Brain Targeting Scope and Limitations
The drug delivery to the brain on systemic administration creates hindrance because of the
presence of blood–brain barrier (BBB). The utilization of novel nanomaterials such as …
presence of blood–brain barrier (BBB). The utilization of novel nanomaterials such as …
From gene to therapy: a review of deciphering the role of ABCD1 in combating X-Linked adrenoleukodystrophy
X Zuo, Z Chen - Lipids in Health and Disease, 2024 - Springer
Abstract X-linked adrenoleukodystrophy (X-ALD) is a severe genetic disorder caused by
ABCD1 mutations, resulting in the buildup of very-long-chain fatty acids, leading to …
ABCD1 mutations, resulting in the buildup of very-long-chain fatty acids, leading to …
Generation and characterization of a zebrafish gain-of-function ACOX1 Mitchell disease model
Q Raas, A Wood, TJ Stevenson, S Swartwood… - Frontiers in …, 2024 - frontiersin.org
Background Mitchell syndrome is a rare, neurodegenerative disease caused by an ACOX1
gain-of-function mutation (c. 710A> G; p. N237S), with fewer than 20 reported cases …
gain-of-function mutation (c. 710A> G; p. N237S), with fewer than 20 reported cases …
Cystic Fibrosis Modulator Therapies: Bridging Insights from CF to other Membrane Protein Misfolding Diseases
Cystic Fibrosis (CF) is a genetic disorder resulting from mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene, leading to a faulty CFTR protein …
transmembrane conductance regulator (CFTR) gene, leading to a faulty CFTR protein …
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DS Rajan, EA Ali - medlink.com
X-linked adrenoleukodystrophy is a progressive neurodegenerative peroxisomal disorder
caused by mutations in the ABCD1 gene, leading to accumulation of very long-chain fatty …
caused by mutations in the ABCD1 gene, leading to accumulation of very long-chain fatty …