NR Klatt, LD Harris, CL Vinton, H Sung, JA Briant… - Mucosal …, 2010 - Elsevier
Pigtail macaques (PTMs) rapidly progress to AIDS after simian immunodeficiency virus (SIV) infection. Given the strong association between human immunodeficiency virus (HIV) and …
KAM Pate, JL Mankowski - Drug discovery today: disease mechanisms, 2011 - Elsevier
Thrombocytopenia is common in HIV and SIV infection, and is often associated with disease progression. HIV and SIV-associated thrombocytopenia arise through multiple mechanisms …
Increased mortality in antiretroviral (ARV)-treated, HIV-infected individuals has been attributed to persistent immune dysfunction, in part due to abnormalities at the …
L Etienne, E Nerrienet, M LeBreton, GT Bibila… - Retrovirology, 2011 - Springer
Background Data on the evolution of natural SIV infection in chimpanzees (SIVcpz) and on the impact of SIV on local ape populations are only available for Eastern African …
The number of HIV-1 positive individuals developing some form of HIV-associated neurocognitive disorder (HAND) is increasing. In these individuals, the integrity of the blood …
NR Klatt, LA Canary, TH Vanderford, CL Vinton… - Journal of …, 2012 - Am Soc Microbiol
Pigtail macaques (PTM) are an excellent model for HIV research; however, the dynamics of simian immunodeficiency virus (SIV) SIVmac239 infection in PTM have not been fully …
LA Canary, CL Vinton, DR Morcock… - The Journal of …, 2013 - journals.aai.org
During HIV/SIV infection, mucosal immune system dysfunction and systemic immune activation are associated with progression to AIDS; however, it is unclear to what extent pre …
Objective Simian immunodeficiency virus (SIV) infection of macaques recapitulates many aspects of HIV pathogenesis and is similarly affected by both genetic and environmental …
MW Breed, SE Elser, W Torben, APO Jordan… - Journal of …, 2015 - Am Soc Microbiol
ABSTRACT Deletion of Gly-720 and Tyr-721 from a highly conserved GYxxØ trafficking signal in the SIVmac239 envelope glycoprotein cytoplasmic domain, producing a virus …