Plasma membrane proteomics and its application in clinical cancer biomarker discovery

R Leth-Larsen, RR Lund, HJ Ditzel - Molecular & Cellular Proteomics, 2010 - ASBMB
Plasma membrane proteins that are exposed on the cell surface have important biological
functions, such as signaling into and out of the cells, ion transport, and cell-cell and cell …

Neurotrophins and their receptors in breast cancer

H Hondermarck - Cytokine & growth factor reviews, 2012 - Elsevier
Growth factors of the neurotrophin family and their receptors have been mainly studied in the
nervous system, but they are also expressed in carcinomas, and in breast cancer they …

Glioma pathophysiology: insights emerging from proteomics

RF Deighton, R McGregor, J Kemp… - Brain …, 2010 - Wiley Online Library
Proteomics is increasingly employed in both neurological and oncological research to
provide insight into the molecular basis of disease but rarely has a coherent, novel …

Biomarker discovery in low-grade breast cancer using isobaric stable isotope tags and two-dimensional liquid chromatography-tandem mass spectrometry (iTRAQ …

P Bouchal, T Roumeliotis, R Hrstka… - Journal of proteome …, 2009 - ACS Publications
The present pilot study constitutes a proof-of-principle in the use of a quantitative LC-MS/MS
based proteomic method for the comparative analysis of representative low-grade breast …

Advances in the proteomic discovery of novel therapeutic targets in cancer

S Guo, J Zou, G Wang - Drug design, development and therapy, 2013 - Taylor & Francis
Proteomic approaches are continuing to make headways in cancer research by helping to
elucidate complex signaling networks that underlie tumorigenesis and disease progression …

Serum protein profiling by solid phase extraction and mass spectrometry: a future diagnostics tool?

AK Callesen, JS Madsen, W Vach, TA Kruse… - …, 2009 - Wiley Online Library
Serum protein profiling by MS is a promising method for early detection of disease. Important
characteristics for serum protein profiling are preanalytical factors, analytical reproducibility …

Research and application of omics and artificial intelligence in cancer

Y Zhang, W Ma, Z Huang, K Liu, Z Feng… - Physics in Medicine …, 2024 - iopscience.iop.org
Cancer has a high incidence and lethality rate, which is a significant threat to human health.
With the development of high-throughput technologies, different types of cancer genomics …

In situ proteomic analysis of human breast cancer epithelial cells using laser capture microdissection: annotation by protein set enrichment analysis and gene …

S Cha, MB Imielinski, T Rejtar, EA Richardson… - Molecular & Cellular …, 2010 - ASBMB
Identification of molecular signatures that allow detection of the transition from normal breast
epithelial cells to malignant invasive cells is a critical component in the development of …

Decoding hidden messengers: proteomic profiling of exosomes in mammary cancer research

AA Novais, GH Tamarindo, LGA Chuffa, DAPC Zuccari - Biomedicines, 2023 - mdpi.com
Cancer is a complex and heterogeneous disease, influenced by various factors that affect its
progression and response to treatment. Although a histopathological diagnosis is crucial for …

Tissue culture‐based breast cancer biomarker discovery platform

V Kulasingam, EP Diamandis - International journal of cancer, 2008 - Wiley Online Library
Current cancer biomarkers suffer from low diagnostic sensitivity and specificity and have not
yet made a major impact on reducing cancer burden. Proteomic methods based on mass …