Taurine is a fundamental mediator of homeostasis that exerts multiple roles to confer
protection against oxidant stress. The development of hypertension, muscle/neuro …

Paracetamol (acetaminophen) is the most commonly used over‐the‐counter (OTC) drug in
the world. Despite its popularity and use for many years, the safety of its application and its …

Changes in adenosine triphosphate (ATP) and peroxynitrite (ONOO–) concentrations have
been correlated in a number of diseases including ischemia-reperfusion injury and drug …

Drug-induced liver injury (DILI) is considered gradually as a serious public health issue, and
hepatotoxicity has been regarded as the main clinical problem caused by it. We suspected …

Nonclinical rodent and nonrodent toxicity models used to support clinical trials of candidate
drugs may produce discordant results or fail to predict complications in humans, contributing …

The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …

The liver is an organ that performs a multitude of functions, and its health is pertinent and
indispensable to survival. Thus, the cellular and molecular machinery driving hepatic …

Acute liver failure (ALF) is a fulminant complication of multiple etiologies, characterized by
rapid hepatic destruction, multi-organ failure and mortality. ALF treatment is mainly limited to …

Paracetamol (acetaminophen) is the most commonly used drug in the world, with a long
record of use in acute and chronic pain. In recent years, the benefits of paracetamol use in …

Current drug-safety assays for hepatotoxicity rely on biomarkers with low predictive power.
The production of radical species, specifically reactive oxygen species (ROS) and reactive …