Notch signaling is evolutionarily conserved and operates in many cell types and at various
stages during development. Notch signaling must therefore be able to generate appropriate …

Extensive studies over the last 30 years have demonstrated that vascular smooth muscle
cell (SMC) differentiation and phenotypic modulation is controlled by a dynamic array of …

Notch signaling is an evolutionarily conserved, intercellular signaling mechanism that plays
myriad roles during vascular development and physiology in vertebrates. These roles …

Endothelial cells and mural cells (smooth muscle cells, pericytes, or fibroblasts) are known
to communicate with one another. Their interactions not only serve to support fully functional …

Calcific aortic valve disease (CAVD) is a major contributor to cardiovascular morbidity and
mortality and, given its association with age, the prevalence of CAVD is expected to continue …

Abstract Noncoding RNAs (long noncoding RNAs and small RNAs) are emerging as critical
modulators of phenotypic changes associated with physiological and pathological contexts …

Notch and transforming growth factor-β (TGFβ) play pivotal roles during vascular
development and the pathogenesis of vascular disease. The interaction of these two …

The evolutionarily conserved NOTCH signaling displays pleotropic functions in almost every
organ system with a simple signaling axis. Different from many other signaling pathways that …

Fibrosis can be defined as an excessive and deregulated deposition of extracellular matrix
proteins, causing loss of physiological architecture and dysfunction of different tissues and …

The Notch signaling pathway is critical for cell fate determination during embryonic
development, including many aspects of vascular development. An emerging paradigm …