Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …

During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

Semaglutide, a glucagon-like peptide 1 (GLP-1) analog, induces weight loss, lowers
glucose levels, and reduces cardiovascular risk in patients with diabetes. Mechanistic …

The cloning of leptin in 1994 was an important milestone in obesity research. In those days
obesity was stigmatized as a condition caused by lack of character and self-control …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

We define the chemoconnectome (CCT) as the entire set of neurotransmitters,
neuromodulators, neuropeptides, and their receptors underlying chemotransmission in an …

Astrocytes are non-neuronal cells that regulate synapses, neuronal circuits, and behavior.
Astrocytes ensheath neuronal synapses to form the tripartite synapse where astrocytes …

Obesity develops when energy intake exceeds energy expenditure over time. Numerous
neurotransmitters, hormones, and factors have been implicated to coordinately control …

Over the past two centuries, prevalent models of energy and glucose homeostasis have
emerged from careful anatomical descriptions in tandem with an understanding of cellular …

In November 1955, Geoffrey Harris published a paper based on the Christian A Herter
Lecture he had given earlier that year at Johns Hopkins University in Baltimore, MD, USA …