Kidney damage varies according to the primary insult. Different aetiologies of acute kidney
injury (AKI), including kidney ischaemia, exposure to nephrotoxins, dehydration or sepsis …

Perioperative hypotension is common and associated with poor outcomes, including acute
kidney injury (AKI). The mechanistic link between perioperative hypotension and AKI is at …

Per gram of tissue, the kidneys are among our most highly perfused organs. Yet the renal
cortex and, in particular, the renal medulla are susceptible to hypoxia. In turn, hypoxia is a …

Acute kidney injury (AKI) is a common complication following cardiac surgery performed on
cardiopulmonary bypass (CPB) and has important implications for prognosis. The aetiology …

Impaired tissue oxygen delivery is a major cause of organ damage and failure in critically ill
patients, which can occur even when systemic parameters, including cardiac output and …

(1) Background: There are no successive treatments for heart failure with preserved ejection
fraction (HFpEF) because of complex interactions between environmental, histological, and …

The kidneys receive~ 25% of cardiac output, which is a prerequisite to maintain sufficient
glomerular filtration rate. However, both intrarenal regional renal blood flow and tissue …

Chronic kidney disease (CKD) is caused by hypoxia in the renal tissue, leading to
inflammation and increased migration of pathogenic cells. Studies showed that leukocytes …

Aim Blood transfusion may improve renal oxygenation during cardiopulmonary bypass
(CPB). In an ovine model of experimental CPB, we tested whether increasing blood …

The renal medulla is prone to hypoxia. Medullary hypoxia is postulated to be a leading
cause of acute kidney injury, so there is considerable interest in predicting the oxygen …