Oncology research in humans is limited to analytical and observational studies for obvious
ethical reasons, with therapy-focused clinical trials being the one exception to this rule …

The intestinal epithelium must balance efficient absorption of nutrients with partitioning
commensals and pathogens from the bodies' largest immune system. If this crucial barrier …

Diagnosis of pancreatic ductal adenocarcinoma (PDAC) is associated with a dismal
prognosis despite current best therapies; therefore new treatment strategies are urgently …

Interspecies blastocyst complementation enables organ-specific enrichment of xenogenic
pluripotent stem cell (PSC) derivatives. Here, we establish a versatile blastocyst …

Here we delineate the ontogeny of the mammalian endoderm by generating 112,217 single-
cell transcriptomes, which represent all endoderm populations within the mouse embryo …

Oncogenic transformation alters lipid metabolism to sustain tumor growth. We define a
mechanism by which cholesterol metabolism controls the development and differentiation of …

Pdx1 is a homeobox-containing transcription factor that plays a key role in pancreatic
development and adult β cell function. In this study, we traced the fate of adult β cells after …

The mammalian intestine is covered by a single layer of epithelial cells that is renewed
every 4–5 days. This high cell turnover makes it a very attractive and comprehensive adult …

To evaluate the role of oncogenic RAS mutations in pancreatic tumorigenesis, we directed
endogenous expression of KRAS G12D to progenitor cells of the mouse pancreas. We find …

The ultimate goal of regenerative medicine is to replace lost or damaged cells. This can
potentially be accomplished using the processes of dedifferentiation, transdifferentiation or …