Skin aging is one of the most evident signs of human aging. Modification of the skin during
the life span is characterized by fine lines and wrinkling, loss of elasticity and volume, laxity …

Cellular senescence is a major contributor to age-related diseases in humans; however, it
also has a beneficial role in physiological and pathological processes, including wound …

Declining tissue nicotinamide adenine dinucleotide (NAD) levels are linked to ageing and its
associated diseases. However, the mechanism for this decline is unclear. Here, we show …

Cellular senescence permanently arrests cell proliferation, often accompanied by a multi-
faceted senescence-associated secretory phenotype (SASP). Loss of mitochondrial function …

Oxidative stress is a major cause of skin injury induced by damaging stimuli such as UV
radiation. Currently, owing to their immunomodulatory properties, mesenchymal stem cell …

Stem cells play central roles in tissue development, homeostasis, and regeneration.
Decades of scientific research have uncovered processes of stem cell decline in tissue and …

Cellular senescence has been shown to contribute to skin ageing. However, the role of
melanocytes in the process is understudied. Our data show that melanocytes are the only …

The skin is comprised of different cell types with different proliferative capacities. Skin aging
occurs with chronological age and upon exposure to extrinsic factors such as photodamage …

Aged skin heals wounds poorly, increasing susceptibility to infections. Restoring
homeostasis after wounding requires the coordinated actions of epidermal and immune …

The aging of the skin is the most visible and obvious manifestation of organismal aging and
may serve as a predictor of life expectancy and health. It is, however, also the human desire …