Sex hormone signaling and regulation of immune function

JP Hoffmann, JA Liu, K Seddu, SL Klein - Immunity, 2023 - cell.com
Immune responses to antigens, including innocuous, self, tumor, microbial, and vaccine
antigens, differ between males and females. The quest to uncover the mechanisms for …

Sex and gender differences in myocarditis and dilated cardiomyopathy: an update

DL Fairweather, DJ Beetler, N Musigk… - Frontiers in …, 2023 - frontiersin.org
In the past decade there has been a growing interest in understanding sex and gender
differences in myocarditis and dilated cardiomyopathy (DCM), and the purpose of this review …

Estrogen receptors regulate innate immune cells and signaling pathways

S Kovats - Cellular immunology, 2015 - Elsevier
Humans show strong sex differences in immunity to infection and autoimmunity, suggesting
sex hormones modulate immune responses. Indeed, receptors for estrogens (ERs) regulate …

The immune system is a natural target for estrogen action: opposing effects of estrogen in two prototypical autoimmune diseases

D Khan, S Ansar Ahmed - Frontiers in immunology, 2016 - frontiersin.org
Analogous to other physiological systems, the immune system also demonstrates
remarkable sex differences. Although the reasons for sex differences in immune responses …

Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis

DP Robinson, SL Klein - Hormones and behavior, 2012 - Elsevier
This article is part of a Special Issue “Neuroendocrine-Immune Axis in Health and Disease.”
During pregnancy, it is evolutionarily advantageous for inflammatory immune responses that …

The Xs and Y of immune responses to viral vaccines

SL Klein, A Jedlicka, A Pekosz - The Lancet infectious diseases, 2010 - thelancet.com
The biological differences associated with the sex of an individual are a major source of
variation, affecting immune responses to vaccination. Compelling clinical data illustrate that …

Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy

D Nakada, H Oguro, BP Levi, N Ryan, A Kitano… - Nature, 2014 - nature.com
Sexually dimorphic mammalian tissues, including sexual organs and the brain, contain stem
cells that are directly or indirectly regulated by sex hormones,,,,,. An important question is …

Sex hormones regulate innate immune cells and promote sex differences in respiratory virus infection

S Kadel, S Kovats - Frontiers in immunology, 2018 - frontiersin.org
Sex differences in the incidence and severity of respiratory virus infection are widely
documented in humans and murine models and correlate with sex biases in numbers and/or …

Phthalate exposure and long-term epigenomic consequences: a review

S Dutta, DK Haggerty, DA Rappolee… - Frontiers in genetics, 2020 - frontiersin.org
Phthalates are esters of phthalic acid which are used in cosmetics and other daily personal
care products. They are also used in polyvinyl chloride (PVC) plastics to increase durability …

The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor α signaling

C Seillet, S Laffont, F Trémollières… - Blood, The Journal …, 2012 - ashpublications.org
Plasmacytoid dendritic cells (pDCs) produce large amounts of type I interferons (IFN-α/β) in
response to viral or endogenous nucleic acids through activation of their endosomal Toll-like …