Role of the extremolytes ectoine and hydroxyectoine as stress protectants and nutrients: genetics, phylogenomics, biochemistry, and structural analysis

L Czech, L Hermann, N Stöveken, AA Richter… - Genes, 2018 - mdpi.com
Fluctuations in environmental osmolarity are ubiquitous stress factors in many natural
habitats of microorganisms, as they inevitably trigger osmotically instigated fluxes of water …

Aerobic methylobacteria as promising objects of modern biotechnology

NV Doronina, ML Torgonskaya, DN Fedorov… - Applied biochemistry …, 2015 - Springer
Aerobic Methylobacteria as Promising Objects of Modern Biotechnology (Review) Page 1
ISSN 0003 6838, Applied Biochemistry and Microbiology, 2015, Vol. 51, No. 2, pp. 125–134 …

Biochemical properties of ectoine hydroxylases from extremophiles and their wider taxonomic distribution among microorganisms

N Widderich, A Hoeppner, M Pittelkow, J Heider… - PloS one, 2014 - journals.plos.org
Ectoine and hydroxyectoine are well-recognized members of the compatible solutes and are
widely employed by microorganisms as osmostress protectants. The EctABC enzymes …

Combining metagenomics with metaproteomics and stable isotope probing reveals metabolic pathways used by a naturally occurring marine methylotroph

C Grob, M Taubert, AM Howat, OJ Burns… - Environmental …, 2015 - Wiley Online Library
A variety of culture‐independent techniques have been developed that can be used in
conjunction with culture‐dependent physiological and metabolic studies of key microbial …

NhaR, LeuO, and H-NS Are Part of an Expanded Regulatory Network for Ectoine Biosynthesis Expression

KE Boas Lichty, GJ Gregory… - Applied and Environmental …, 2023 - Am Soc Microbiol
Bacteria accumulate compatible solutes to maintain cellular turgor pressure when exposed
to high salinity. In the marine halophile Vibrio parahaemolyticus, the compatible solute …

New insights into hydroxyectoine synthesis and its transcriptional regulation in the broad‐salt growing halophilic bacterium Chromohalobacter salexigens

M Argandona, F Piubeli, M Reina‐Bueno… - Microbial …, 2021 - Wiley Online Library
Elucidating the mechanisms controlling the synthesis of hydroxyectoine is important to
design novel genetic engineering strategies for optimizing the production of this …

CosR is a global regulator of the osmotic stress response with widespread distribution among bacteria

GJ Gregory, DP Morreale, EF Boyd - Applied and Environmental …, 2020 - Am Soc Microbiol
Bacteria accumulate small, organic compounds called compatible solutes via uptake from
the environment or biosynthesis from available precursors to maintain the turgor pressure of …

GlnR-Mediated Regulation of ectABCD Transcription Expands the Role of the GlnR Regulon to Osmotic Stress Management

ZH Shao, WX Deng, SY Li, JM He, SX Ren… - Journal of …, 2015 - Am Soc Microbiol
Ectoine and hydroxyectoine are excellent compatible solutes for bacteria to deal with
environmental osmotic stress and temperature damages. The biosynthesis cluster of ectoine …

Complete genome sequence of Microbulbifer sp. CCB-MM1, a halophile isolated from Matang Mangrove Forest, Malaysia

TH Moh, NS Lau, G Furusawa, AAA Amirul - Standards in Genomic …, 2017 - Springer
Microbulbifer sp. CCB-MM1 is a halophile isolated from estuarine sediment of Matang
Mangrove Forest, Malaysia. Based on 16S rRNA gene sequence analysis, strain CCB-MM1 …

LeuO and H-NS are part of an expanded regulatory network for ectoine biosynthesis expression

K Boas Lichty, GJ Gregory, EF Boyd - bioRxiv, 2022 - biorxiv.org
Bacteria accumulate compatible solutes, to maintain cellular turgor pressure when exposed
to high salinity. In the marine halophile Vibrio parahaemolyticus, the compatible solute …