Ageing is a complex trait controlled by genes and the environment. The highly conserved
mechanistic target of rapamycin signalling pathway (mTOR) is a major regulator of lifespan …

The fission yeast Schizosaccharomyces pombe employs two main strategies to adapt to the
environment and survive when starved for nutrients. The strategies employ sporulation via …

The packaging of the genetic material into chromatin imposes the remodeling of this barrier
to allow efficient transcription. RNA polymerase II activity is coupled with several histone …

Summary Target of Rapamycin Complex 1 (TORC1) signaling promotes growth and aging.
Inhibition of TORC1 leads to reduced protein translation, which promotes longevity. TORC1 …

The fission yeast Schizosaccharomyces pombe is an excellent model organism to explore
cellular events owing to rich tools in genetics, molecular biology, cellular biology, and …

In the fission yeast Schizosaccharomyces pombe, the duration of survival in the stationary
phase, termed the chronological lifespan (CLS), is affected by various environmental factors …

Nutrient availability has a profound impact on cell fate. Upon nitrogen starvation, wild-type
fission yeast cells uncouple cell growth from cell division to generate small, round-shaped …

The stress response is one of the most fundamental cellular processes. Although the
molecular mechanisms underlying responses to a single stressor have been extensively …

Leucine (Leu) is a branched-chain, essential amino acid in animals, including humans.
Fungi, including the fission yeast Schizosaccharomyces pombe, can biosynthesize Leu, but …

Non-coding RNAs (ncRNAs) ubiquitously exist in normal and cancer cells. Despite their
prevalent distribution, the functions of most long ncRNAs remain uncharacterized. The …