Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …

Mitochondria are dynamic organelles that continually move, fuse and divide. The dynamic
balance of fusion and fission of mitochondria determines their morphology and allows their …

Membrane organelles comprise both proteins and lipids. Remodeling of these membrane
structures is controlled by interactions between specific proteins and lipids. Mitochondrial …

Mitochondria play central roles in cellular energetics, metabolism and signalling. Efficient
respiration, mitochondrial quality control, apoptosis and inheritance of mitochondrial DNA …

The elaborate membrane architecture of mitochondria is a prerequisite for efficient
respiration and ATP generation. The cristae membranes, invaginations of the inner …

The distinctive pathological hallmarks of Parkinson's disease are the progressive death of
dopaminergic neurons and the intracellular accumulation of Lewy bodies enriched in α …

The cellular lipidome comprises thousands of unique lipid species. Here, using mass
spectrometry-based targeted lipidomics, we characterize the lipid landscape of human and …

The Rad50 interacting protein 1 (Rint1) is a key player in vesicular trafficking between the
ER and Golgi apparatus. Biallelic variants in RINT1 cause infantile-onset episodic acute …

Sphingolipids contain in their polar heads chemical groups allowing them to establish a
complex network of H-bonds (through different single bondOH and single bondNHsingle …

Diabetic encephalopathy (DE) is a common central nervous system complication of diabetes
mellitus without effective therapy currently. Recent studies have highlighted synaptic …