Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic
development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is …

Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS), affect millions of people …

Understanding how neurodegenerative disorders develop is not only a key challenge for
researchers but also for the wider society, given the rapidly aging populations in developed …

Meninges are a three tissue membrane primarily known as coverings of the brain. More in
depth studies on meningeal function and ultrastructure have recently changed the view of …

Acute leukemias (both myeloid and lymphoblastic) are a group of diseases for which each
year more successful therapies are implemented. However, in a subset of cases the overall …

In mammals, new neurons can be generated from neural stem cells in specific regions of the
adult brain. Neural stem cells are characterized by their abilities to differentiate into all …

Glial scars are a common pathological occurrence in a variety of central nervous system
(CNS) diseases and injuries. They are caused after severe damage and consist of reactive …

Within the adult central nervous system (CNS) of most mammals resides a resident stem cell
population, known as neural stem cells (NSCs). NSCs are located within specific niches of …

Neurodegenerative disorders are one of the leading causes of death and disability and one
of the biggest burdens on health care systems. Novel approaches using various types of …

Emerging evidence highlights the several roles that meninges play in relevant brain
functions as they are a protective membrane for the brain, produce and release several …