Construction is a physically demanding occupation that requires workers to exert
themselves when executing tasks. Many construction tasks involve manual handling …

Ensaios clínicos randomizados (ECR) são o padrão ouro para desenho experimental de
estudo ou ensaio clínico. Apenas por meio de uma investigação do tipo ECR é possível …

BACKGROUND: Randomized controlled trial (RCT) is the gold standard of experimental
design or clinical trial design. Only by RCT in research, the cause-and-effect relationship …

Abstract Response-Adaptive Randomization (RAR) is part of a wider class of data-
dependent sampling algorithms, for which clinical trials are typically used as a motivating …

Adaptive Designs for Sequential Treatment Allocation presents a rigorous theoretical
treatment of the results and mathematical foundation of adaptive design theory. The book …

The aim of this integrative literature review was to evaluate the efficacy and safety of
Metformin as an add-on therapy to insulin in poorly controlled overweight adolescents with …

Biased-coin designs are used in clinical trials to allocate treatments with some randomness
while maintaining approximately equal allocation. More recent rules are compared with …

A thorough knowledge of biases in intervention studies and how they influence study results
is essential for the practice of evidence-based medicine. The objective of this review was to …

Background Randomized controlled trial (RCT) data have important implications in drug
development. However, the feasibility and cost of conducting RCTs lower the motivation for …

We consider optimal design problems for dose-finding studies with censored Weibull time-to-
event outcomes. Locally D-optimal designs are investigated for a quadratic dose–response …