Blood–brain barrier structure and function and the challenges for CNS drug delivery
NJ Abbott - Journal of inherited metabolic disease, 2013 - Springer
The neurons of the central nervous system (CNS) require precise control of their bathing
microenvironment for optimal function, and an important element in this control is the blood …
microenvironment for optimal function, and an important element in this control is the blood …
A pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challenges
M Oshimura, N Uno, Y Kazuki, M Katoh, T Inoue - Chromosome Research, 2015 - Springer
Microcell-mediated chromosome transfer (MMCT) is a technique to transfer a chromosome
from defined donor cells into recipient cells and to manipulate chromosomes as gene …
from defined donor cells into recipient cells and to manipulate chromosomes as gene …
De novo formed satellite DNA-based mammalian artificial chromosomes and their possible applications
RL Katona - Chromosome Research, 2015 - Springer
Mammalian artificial chromosomes (MACs) are non-integrating, autonomously replicating
natural chromosome-based vectors that may carry a vast amount of genetic material, which …
natural chromosome-based vectors that may carry a vast amount of genetic material, which …
Progress and prospects: human artificial chromosomes
S Macnab, A Whitehouse - Gene therapy, 2009 - nature.com
Artificial chromosomes (ACs) are highly promising vectors for use in gene therapy
applications. They are able to maintain expression of genomic-sized exogenous transgenes …
applications. They are able to maintain expression of genomic-sized exogenous transgenes …
Mesenchymal Stromal Cells' Therapy for Polyglutamine Disorders: Where Do We Stand and Where Should We Go?
Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders
caused by the expansion of the cytosine-adenine-guanine (CAG) repeat. This mutation …
caused by the expansion of the cytosine-adenine-guanine (CAG) repeat. This mutation …
Novel method to load multiple genes onto a mammalian artificial chromosome
A Toth, K Fodor, T Praznovszky, V Tubak, A Udvardy… - PLoS …, 2014 - journals.plos.org
Mammalian artificial chromosomes are natural chromosome-based vectors that may carry a
vast amount of genetic material in terms of both size and number. They are reasonably …
vast amount of genetic material in terms of both size and number. They are reasonably …
New vectors for gene delivery: human and mouse artificial chromosomes
M Oshimura, Y Kazuki, Y Iida, N Uno - eLS, 2013 - Wiley Online Library
Human artificial chromosomes (HACs) have been generated mainly by either a 'top-down
approach'(engineered creation) or a 'bottom-up approach'(de novo creation). HACs with …
approach'(engineered creation) or a 'bottom-up approach'(de novo creation). HACs with …
Engineered chromosomes in transgenics
Horizontal gene transfer or simply transgenic technology has evolved much since 1980.
Gene delivery strategies, systems, and equipments have become more and more precise …
Gene delivery strategies, systems, and equipments have become more and more precise …
Novel method to load a mammalian artificial chromosome with multiple genes
R Katona, G Hadlaczky, K Fodor… - US Patent App. 14 …, 2014 - Google Patents
(21) Appl. No.: 14/349,767 The invention provides for a system for uploading genes of 1-1.
interest into an artificial chromosome expression system (22) PCT Filed: Nov. 15, 2013(ACE) …
interest into an artificial chromosome expression system (22) PCT Filed: Nov. 15, 2013(ACE) …
[HTML][HTML] Human Artificial Chromosomes and Their Transfer to Target Cells
SV Ponomartsev, SA Sinenko, AN Tomilin - Acta Naturae, 2022 - ncbi.nlm.nih.gov
Human artificial chromosomes (HACs) have been developed as genetic vectors with the
capacity to carry large transgenic constructs or entire gene loci. HACs represent either …
capacity to carry large transgenic constructs or entire gene loci. HACs represent either …