Loss of TDP‐43 oligomerization or RNA binding elicits distinct aggregation patterns

M Pérez‐Berlanga, VI Wiersma, A Zbinden… - The EMBO …, 2023 - embopress.org
Aggregation of the RNA‐binding protein TAR DNA‐binding protein 43 (TDP‐43) is the key
neuropathological feature of neurodegenerative diseases, including amyotrophic lateral …

Biomolecular condensates as stress sensors and modulators of bacterial signaling

M Sasazawa, DT Tomares, WS Childers… - PLoS …, 2024 - journals.plos.org
Microbes exhibit remarkable adaptability to environmental fluctuations. Signaling
mechanisms, such as two-component systems and secondary messengers, have long been …

Oxidative regulation of TDP-43 self-association by a β-to-α conformational switch

J Gu, X Zhou, L Sutherland, M Kato… - Proceedings of the …, 2023 - National Acad Sciences
An evolutionarily conserved region of the TDP-43 low-complexity domain (LCD) twenty
residues in length can adopt either an α-helical or β-strand conformation. When in the latter …

Protein domains of low sequence complexity—dark matter of the proteome

SL McKnight - Genes & development, 2024 - genesdev.cshlp.org
This perspective begins with a speculative consideration of the properties of the earliest
proteins to appear during evolution. What did these primitive proteins look like, and how …

VAMP2 regulates phase separation of α-synuclein

A Agarwal, A Chandran, F Raza, IM Ungureanu… - Nature Cell …, 2024 - nature.com
Abstract α-Synuclein (αSYN), a pivotal synaptic protein implicated in synucleinopathies such
as Parkinson's disease and Lewy body dementia, undergoes protein phase separation. We …

Rapid and reversible dissolution of biomolecular condensates using light-controlled recruitment of a solubility tag

EH Brumbaugh-Reed, Y Gao, K Aoki… - Nature …, 2024 - nature.com
Biomolecular condensates are broadly implicated in both normal cellular regulation and
disease. Consequently, several chemical biology and optogenetic approaches have been …

[HTML][HTML] How the circadian nuclear orphan receptor REV-ERBα represses transcription: Temporal and spatial phase separation combined

U Schibler - Molecular Cell, 2023 - cell.com
How the circadian nuclear orphan receptor REV-ERBα represses transcription: Temporal and
spatial phase separation combined: Molecular Cell Skip to Main Content Advertisement …

Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis …

H Uechi, S Sridharan, J Nijssen, J Bilstein… - bioRxiv, 2019 - biorxiv.org
Neurodegeneràve diseases such as amyotrophic lateral sclerosis (ALS) are oten associated
with mutàons in proteins that are associated with stress granules. Stress granules are …