Piperidine nucleus as a promising scaffold for alzheimer's disease: current landscape and future perspective
Heterocycles and their derivatives hold an important place in medicinal chemistry due to
their vast therapeutic and pharmacological significance and wider implications in drug …
their vast therapeutic and pharmacological significance and wider implications in drug …
Synthesis, characterization, and in vitro antibacterial activity of some new pyridinone and pyrazole derivatives with some in silico ADME and molecular modeling study
KE Saadon, NMH Taha, NA Mahmoud… - Journal of the Iranian …, 2022 - Springer
A new series of pyridine-2-one and pyrazole derivatives were designed and synthesized
based on cyanoacrylamide derivatives containing 2, 4-dichlro aniline and 6-methyl 2-amino …
based on cyanoacrylamide derivatives containing 2, 4-dichlro aniline and 6-methyl 2-amino …
Benzimidazole and Benzoxazole Derivatives Against Alzheimer's Disease
N Faydalı, ÖT Arpacı - Chemistry & Biodiversity, 2024 - Wiley Online Library
Benzimidazole and benzoxazole derivatives are included in the category of medical drugs in
a wide range of areas such as anticancer, anticoagulant, antihypertensive, anti …
a wide range of areas such as anticancer, anticoagulant, antihypertensive, anti …
Synthesis, bioinformatics and biological evaluation of novel pyridine based on 8-hydroxyquinoline derivatives as antibacterial agents: DFT, molecular docking and …
The present study aims to first explore the relationship between the chemical structure of the
organic compounds (pyridine based on 8-hydroxyquinoline) and the antibacterial activities …
organic compounds (pyridine based on 8-hydroxyquinoline) and the antibacterial activities …
Are clarithromycin, azithromycin and their analogues effective in the treatment of COVID19
BACKGROUND: SARS-CoV-2, which started in Wuhan and later affected the whole world, is
the most important disease of the world today. Many ways to inhibit SARS-CoV-2 virus are …
the most important disease of the world today. Many ways to inhibit SARS-CoV-2 virus are …
Flavone-based hydrazones as new tyrosinase inhibitors: Synthetic imines with emerging biological potential, SAR, molecular docking and drug-likeness studies
Targeting tyrosinase (TYR), a key enzyme responsible for melanogenesis disorders, is a
well-known approach utilized for the development of melanogenesis inhibitor. A variety of …
well-known approach utilized for the development of melanogenesis inhibitor. A variety of …
The biological activities, molecular docking studies, and anticancer effects of 1-arylsuphonylpyrazole derivatives
This work is devoted to definition of the direction of reaction between 1-
benzenesulfonylimino pyridinium chloride and α-or β-halo-containing sulfamides …
benzenesulfonylimino pyridinium chloride and α-or β-halo-containing sulfamides …
In vitro bioactivities and in silico enzyme interactions of abietatrien-3β-ol by bio-guided isolation from Nepeta italica subsp. italica
Abstract Abietatrien-3 β-ol (ATO) was isolated from the aerial part of the Nepeta italica
subsp. italica methanol-chloroform extract and studied antioxidant, enzyme inhibition, and …
subsp. italica methanol-chloroform extract and studied antioxidant, enzyme inhibition, and …
Synthesis, molecular docking, molecular dynamics, DFT and antimicrobial activity studies of 5-substituted-2-(p-methylphenyl) benzoxazole derivatives
Abstract In this study, new 2-(p-methylphenyl)-5-(2-substitutedacetamido) benzoxazole
derivatives were synthesized, and antimicrobial activities on six bacteria and their twelve …
derivatives were synthesized, and antimicrobial activities on six bacteria and their twelve …
Structure-based designing and synthesis of 2-phenylchromone derivatives as potent tyrosinase inhibitors: In vitro and in silico studies
J Ashraf, EU Mughal, RI Alsantali, RJ Obaid… - Bioorganic & Medicinal …, 2021 - Elsevier
The present study describes the discovery of novel inhibitors of mushroom tyrosinase
enzyme. For that purpose, a series of varyingly substituted 2-phenylchromone analogues 1 …
enzyme. For that purpose, a series of varyingly substituted 2-phenylchromone analogues 1 …