The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …

The six members of the family of insulin-like growth factor (IGF) binding proteins (IGFBPs)
were originally characterized as passive reservoirs of circulating IGFs, but they are now …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths
worldwide. Only 30%-40% of the patients with HCC are eligible for curative treatments …

Thyroid-associated ophthalmopathy (TAO) is a complex disease process presumed to
emerge from autoimmunity occurring in the thyroid gland, most frequently in Graves disease …

The growing demands of advanced fluorescence and super‐resolution microscopy benefit
from the development of small and highly photostable fluorescent probes. Techniques …

Despite a strong preclinical rationale for targeting the insulin-like growth factor (IGF) axis in
cancer, clinical studies of IGF-1 receptor (IGF-1R)-targeted monotherapies have been …

Insulin-like growth factor 1 (IGF1) is a peptide growth factor with important functions in
multiple aspects of growth, development and metabolism. The biological actions of IGF1 are …

The insulin-like growth factor type 1 receptor (IGF-1R) plays a key role in the development
and progression of cancer; however, therapeutics targeting it have had disappointing results …

The insulin-like growth factor (IGF) family plays key roles in growth and development. In the
cornea, IGF family members have been implicated in proliferation, differentiation, and …

Insulin-like Growth Factor (IGF)/IGF-1 Receptor (IGF-1R) signaling is known to regulate stem
cell pluripotency and differentiation to trigger cell proliferation, organ development, and …