The ability to reprogram the transcriptional circuitry by remodeling the three-dimensional
structure of the genome is exploited by cancer cells to promote tumorigenesis. This …

MicroRNAs (miRNAs) are widely present in many organisms and regulate the expression of
genes in various biological processes such as cell differentiation, metabolism, and …

Background Lung cancer is still one of the most serious causes of cancer‐related deaths all
over the world. Micro RNA s (mi RNA s) are defined as small non‐coding RNA s which could …

Tumor metastasis is a hallmark of cancer, with distant metastasis frequently developing in
lung cancer, even at initial diagnosis, resulting in poor prognosis and high mortality …

Epigenetic research has the potential to improve our understanding of the pathogenesis of
cancer, specifically non-small-cell lung cancer, and support our efforts to personalize the …

The molecular mechanisms by which lymphatic vessels induce cell contact inhibition are not
understood. Here, we identify the cGMP-dependent phosphodiesterase 2A (PDE2A) as a …

MicroRNAs (miRNAs) have been reported to be involved in many human cancers and tumor
progression. The dysregulation of miR-449a is found in many types of malignancies and is …

Despite major advances, non-small cell lung cancer (NSCLC) remains the major cause of
cancer-related death in developed countries. Metastasis and drug resistance are the main …

We recently determined the RNA sequencing-based microRNA (miRNA) expression
signature of colorectal cancer (CRC). Analysis of the signature showed that the expression …

Lung cancer remains the most diagnosed cancer in the world, with a high mortality rate and
fewer therapeutic options. The most common lung cancer is non-small cell, consisting of …